Little information is yet available about the effect of prolonged muscle disuse on neural stem cells characteristics our in vitro study aims to fill this gap by focusing on the biological and molecular properties of neural stem cells (nscs.
Neural stem cells (nscs) are self-renewing, multipotent cells that generate the neurons and glia of the nervous system of all animals during embryonic development some neural stem cells persist in the adult vertebrate brain and continue to produce neurons throughout life.
Therefore, we undertook a systematic analysis of the effects of age on stem and progenitor cells in the mouse brain by examining the number of brdu +ve cells (assaying all dividing cells) and sfcs (assaying nscs and more restricted progenitor cells) within the pvr along the lateral ventricles. Epidermal growth factor (egf) and fibroblast growth factor (fgf) are mitogens that promote neural progenitor and stem cell growth in vitro, though other factors synthesized by the neural progenitor and stem cell populations are also required for optimal growth it is hypothesized that neurogenesis in the adult brain originates from nscs. When the term “stem cell” was used 25 years ago, the context was typically adult tissue homeostasis, mouse genetics, or early development thanks to several landmark advances in the area of developmental neurobiology, neural stem cells (nscs) are now central to our discussion of how the brain forms.
Complexity of neural stem cell niche in the adult mammalian brain the neural stem cells persist in a typical neurogenic niche known as the subventricular zone (svz) svz neural stem cells (nscs) are self-renewing and multipotent in culture in rodents, the adult nscs correspond to svz astrocytes (type b cells) which are derived from radial glia. On the effects of neural stem/progenitor cells (nsc) transplants in the aged pd brain here, l’epis- copo and coworkers studied the effects of unilateral transplantation of syngeneic somatic nscs.
Stem cell brain implants could 'slow ageing and extend life', study shows that wiped out 70% of their neural stem cells the effect was striking cells were removed during early ageing.
Scientists at albert einstein college of medicine have found that stem cells in the brain's hypothalamus govern how fast aging occurs in the body the finding, made in mice, could lead to new strategies for warding off age-related diseases and extending lifespan.